New research indicates that patients who come off new slimming jabs like Mounjaro or Wegovy may regain shed pounds at a significantly accelerated pace than those who stop traditional diet and exercise regimens.
Findings released in a prominent health publication demonstrates that while obese individuals often shed about a fifth of their body weight while using the jabs, the weight is regained at an estimated rate of nearly a kilo each month after stopping.
"Users purchasing such medications must be cognizant of the risk of rapid weight regain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original mass within about 18 months.
Comparing Approaches
The study, which looked at 37 of trials involving thousands of participants, contrasted the outcomes of these new drugs with older methods.
Researchers note that individuals who lose weight through dieting generally have a more gradual creep back—perhaps 100 grams monthly—after stopping.
Understanding the Fast Rebound
Doctors propose the mode of action of the drugs accounts for the accelerated rebound.
These medications copy a body's own chemical called GLP-1, which controls appetite.
"Sustained high doses of the hormone levels several times higher than normal could lead to the body to generate a reduced amount of its endogenous hormone, and could diminish responsiveness to its actions," said Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this hormone supplement results in appetite is unsuppressed, making binge eating much more probable."
An Ongoing Condition?
Health authorities recommend the jabs for people with weight-linked medical conditions, alongside prescribed lifestyle changes.
A number of clinicians say that, considering the significant potential of relapse, the therapy might need to be long-term.
This view is supported by drug manufacturers, who note that the results "highlight the persistent nature of excess weight," similar to managing diseases like high blood pressure.
Patient Accounts
Individuals who have discontinued the medication report a intense resurgence of appetite.
"It was like a trigger activating and you're instantly ravenous," recalled an individual.
This challenge is exacerbated if patients have not established permanent lifestyle or habit modifications during therapy.
Growing Interest
Figures show that a significant number of people in the UK have used these injections in the past year, with interest remaining high.
- Use is greater among females than males.
- The middle-aged age group shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than the NHS.
In conclusion, researchers caution that while GLP-1 drugs are powerful agents for shedding pounds, they are not a magic cure and lasting health benefits hinges on ongoing lifestyle support.
